Availability of Lactating Cow Intramammary Antibiotics

Veterinary Medicines Directorate

February 26
12:02 2021

Marketing Authorisation Holders (MAHs) have informed the VMD of supply problems with the following lactating cow intramammary antibiotics.

Product Anticipated Resolution Date (subject to change)
Tetra-Delta Intramammary Suspension (42058/4152) Second half of 2021
Ubro Yellow Milking Cow Intramammary Suspension (08327/4305) Product discontinued no return date
Multiject IMM Intramammary Suspension (02000/4062) Spring 2022
Albiotic 330mg/100mg Intramammary Solution (30282/4035) Mid-February 2021
Combiclav Intramammary Suspension for Lactating Cows (02000/4424) Autumn 2022
Cefimam LC, 75 mg Intramammary Ointment for Lactating Cows (02000/4387)* Product discontinued no return date

The following lactating cow intramammary products have been reported as available for veterinary surgeons to purchase:

Product Contact Details
Ubropen 600 mg Intramammary Suspension for Lactating Cows (42810/4000) Boehringer Ingelheim Animal Health UK Ltd 01344 746957 or
Ubrolexin Intramammary Suspension for Lactating Dairy Cows (08327/4306) Boehringer Ingelheim Animal Health UK Ltd 01344 746957 or
Procapen Injector 3g intramammary suspension for cattle (24745/4023) FORTE Healthcare Limited +353 1 841 7666 or
Synulox Lactating Cow Intramammary Suspension (42058/4143) Zoetis UK Limited 0845 300 8034 or
Orbenin L.A. 200mg Intramammary Suspension (42058/4090) Zoetis UK Limited 0845 300 8034 or
Pathocef 250mg Intramammary Suspension (42058/4094)* Zoetis UK Limited 0845 300 8034 or
Cobactan MC Intramammary Suspension for Lactating Cows (01708/4444)* MSD Animal Health UK Limited 01908 665050 or
Mastiplan LC, 300mg/20mg Intramammary Suspension (01708/4534) MSD Animal Health UK Limited 01908 665050 or

Note: * These are defined as a Highest Priority Critically Important Antibiotics for human medicine and, under the Red Tractor farm assurance scheme for beef and dairy, should be used as a last resort and supported by sensitivity and/or diagnostic testing.

For further details of the supply situation for individual UK-authorised products, please contact the MAH or a wholesale dealer.

During this time, the VMD acknowledges that the availability of veterinary medicines must be balanced with the protection of animal health, human health and the environment.

The VMD supports and encourages the responsible use of antibiotics. This however, requires veterinary surgeons to take into consideration, not only the most appropriate active substance(s) but also the most appropriate formulation, the posology, the current pattern of resistance in their locality, an awareness of how to reduce selection pressure (considering MICs and clinical breakpoints when available) and adjunctive requirements (such as good biosecurity and husbandry/hygiene, avoiding surgical sepsis etc). If a veterinary surgeon can demonstrate that these steps have been taken, then cascade use of antibiotics may be considered. Antibiotics should not be used to compensate for poor hygiene or inadequate husbandry and biosecurity measures.

Therefore, if veterinary surgeons deem the available products (listed above) unsuitable for their clinical need, and identify and wish to use an alternative product authorised outside of the UK to cover their immediate needs, an import certificate application may be submitted to the VMD.

Applications should only be submitted after attempts to obtain suitable UK authorised veterinary products have been unsuccessful, and each application will be assessed on its individual merits and justification. Cost or convenience are not considered suitable justification for use of the cascade. Veterinary surgeons are also reminded to consider the likely quantities needed and purchase appropriately.

For additional resources and information on responsible use of antibiotics, please visit

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